Words similar to adrenergic
Example sentences for: adrenergic
How can you use “adrenergic” in a sentence? Here are some example sentences to help you improve your vocabulary:
Down-regulation occurs after prolonged agonist treatment (hours to days), resulting in a loss of receptor binding sites [ 2 3 4 ] . The processes involved in homologous desensitization have been extensively investigated for the beta-2 adrenergic receptor, which is the prototypical G protein-coupled receptor.
One such example is shown in Figure 1. The gene CG18314 encodes a G-protein-coupled receptor of the rhodopsin family, containing a seven-transmembrane protein domain with similarity to β 2 -adrenergic receptors of mouse and human [ 30, 31].
The phosphorylated beta-2 receptor enhances the binding of beta-arrestin, which not only uncouples the receptor from the signal transduction process but also serves as an adapter protein that mediates entry into the internalization pathway [ 5 ] , as well as serving as a platform for additional signaling pathways [ 6 ] . The mechanisms of beta-2 adrenergic receptor down-regulation appear to involve both an increase in the rate of degradation of the receptor as well as a decrease in the levels of beta receptor mRNA [ 7 ] . Down-regulation of the beta-2 receptor is, in part, due to trafficking of the beta-2 receptor to lysosomes via the clathrin-coated pit endosomal pathway [ 8 9 ] .
In adrenergic receptors, which have been characterized in detail, rapid endocytosis appears to be required for resensitization of receptors following agonist-induced phosphorylation ( 28).
As can be seen from the results in Table 3, this does not appear to be a common motif for G protein-coupled receptors, not even for alpha-2 adrenergic receptors.
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