Words similar to adrenergic
Example sentences for: adrenergic
How can you use “adrenergic” in a sentence? Here are some example sentences to help you improve your vocabulary:
The human alpha-2C receptor is somewhat unique among the alpha-2 receptors in that it does not appear to undergo agonist-induced down-regulation [ 11 ] . The human alpha-2A adrenergic receptor, which does undergo down-regulation, has an acidic serine motif (EESSSSD) in the third intracellular loop.
The phosphorylated beta-2 receptor enhances the binding of beta-arrestin, which not only uncouples the receptor from the signal transduction process but also serves as an adapter protein that mediates entry into the internalization pathway [ 5 ] , as well as serving as a platform for additional signaling pathways [ 6 ] . The mechanisms of beta-2 adrenergic receptor down-regulation appear to involve both an increase in the rate of degradation of the receptor as well as a decrease in the levels of beta receptor mRNA [ 7 ] . Down-regulation of the beta-2 receptor is, in part, due to trafficking of the beta-2 receptor to lysosomes via the clathrin-coated pit endosomal pathway [ 8 9 ] .
It is commonly believed that hypokalemia identified during the acute phase of SAH is caused by a catecholamine surge following SAH [ 2 ] . In healthy male volunteers, Brown and coworkers [ 5 ] demonstrated that serum infused adrenaline (epinephrine) caused excessive activation of the sodium/potassium-ATPase (Na +/K +-ATPase; Na +/K +pump) as a result of β 2 -adrenergic receptor stimulation; this resulted in trafficking of potassium ions from extracellular to intracellu-lar spaces, leading to a decrease in serum potassium levels.
Sheridan [ 49 ] and Iaccarino [ 35 ] came to a similar conclusion regarding heart failure and adrenergic down-regulation.
Recently, it has been noted that the JNK and p38 pathways can be activated by G-protein coupled receptor agonists, notably angiotensin II, in vascular smooth muscle cells [ 19 20 ] . In cardiac myocytes, both the p38 and JNK pathways have been activated by endothelin-1 (ET-1) and the α 1 adrenergic receptor agonist phenylephrine [ 21 ] . The ability of the JNK and p38 pathways to be activated by the same agonists of G-protein coupled receptors which activate the ERK pathway led to the investigation of 5-HT as a possible activator of the JNK and p38 pathways.
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