Words similar to adrenergic
Example sentences for: adrenergic
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Urinary incontinence as a result of olanzapine [ 12 ] or clozapine [ 15 ] therapy was treated effectively with ephedrine (alpha adrenergic receptor agonist), suggesting a possible alpha1 effect.
The literature surrounding norepinephrine and its role in the development of iron deficient hypertrophy documents the following facts: 1) prolonged iron deficiency causes cardiac hypertrophy [ 11 12 13 14 15 16 17 23 ] , 2) the pool of stored norepinephrine in the heart is decreased with iron deficiency [ 17 21 ] , 3) plasma and urine concentrations of norepinephrine are increased with iron deficiency [ 19 20 21 22 68 ] , and 4) chronic administration of reserpine (which depletes norepinephrine) prevents the development of iron deficient hypertrophy [ 12 ] , but not hypertrophy that results from aortic banding [ 23 ] . This, combined with other studies that relate chronic adrenergic stimulation to hypertrophy, led Rossi to the conclusion that iron deficiency hypertrophy was caused by chronic sympathetic stimulation.
There are three subtypes of the alpha-2 adrenergic receptor: alpha-2A; alpha-2B; and alpha-2C [ 15 ] . The human alpha-2A subtype undergoes phosphorylation and short-term desensitization [ 11 12 ] , whereas the human alpha-2C subtype is not phosphorylated [ 16 ] and does not desensitize [ 11 ] . The human alpha-2C subtype, however, does undergo arrestin-dependent internalization [ 17 ] . Many studies [ 11 18 ] , including those from our laboratory [ 10 19 20 ] , have demonstrated agonist-induced down-regulation of alpha-2 receptors, although much less is known about the specific mechanisms for down-regulation as compared to the beta-2 receptor.
In anesthetized rats, doxazosin (alpha 1 adrenergic receptor antagonist) administered systemically, increased micturition volume, bladder capacity, residual volume and micturition frequency while decreasing peak pressure [ 36 ] . Only an increase in the micturition frequency was observed after spinal administration of doxazosin [ 37 ] . Both olanzapine and risperidone have moderate affinity for the alpha 1 adrenergic receptor (Table 1), therefore it is possible that some of the effects observed in the present study were due to central and/or peripheral antagonism of alpha 1 adrenergic receptors by these drugs.
To screen for the presence of the mutation, the alpha-2 adrenergic receptor insert was cut from the vector using Hind III (895) and EcoR1 (1841) and cut with Ddel.
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