Words similar to adam-

Example sentences for: adam-

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This proposal is supported by recent evidence that either genetic modification of ADAM-10/α-secretase activity [67] or administration of bryostatin, a PKC activator [68], can modulate levels of brain Aβ in plaque-forming transgenic mice.
We interpret this as an indication that the statin-induced α-cleavage of APP is probably mediated by one of the molecules usually associated with the phenomenon, i.e., ADAM-10 or ADAM-17 [16].
APP can also be cleaved by the nonamyloidogenic α-secretases, a disintegrin and metalloproteinase 10 (ADAM-10) and ADAM-17 [3], in a reaction that is believed to occur primarily on the plasma membrane [4] and is known as “ectodomain shedding.”
These investigators proposed that elevated ADAM-10 activity and protein levels contributed to these effects.
Ultimately, the integral cell-surface metalloproteinases ADAM-10 and ADAM-17/TACE were found to underlie α-secretase-type ectodomain shedding [3,46].