Words similar to actomyosin
Example sentences for: actomyosin
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For example, growth factor-induced localization of actin mRNA to the leading edge of fibroblasts is a dynamic, regulated process requiring actomyosin interactions and activation of the RhoGTPase pathway, as well as specific signal sequences in the 3' UTR of the message [ 9 10 11 12 ] . Moreover, disruption of the actin cytoskeleton using pharmacological agents also blocks the association of β-actin mRNA with microfilaments and prevents localization of the transcript to the cell periphery [ 7 13 ] . Mechanical forces exerted on cell surface integrin receptors, which anchor the actin cytoskeleton to the extracellular matrix, also produce changes in the localization of poly(A) mRNA and ribosomal proteins inside the cell [ 14 ] . Importantly, the localization of transcripts can serve as a key regulatory step in gene expression as inhibition of mRNA targeting can significantly impact cell function.
In panel C, type I (dark stain), IIa (light stain), and IIb-IId/x (intermediate stain) fibers can be identified based on the myofibrillar actomyosin ATPase histochemical staining procedure [ 18 ] . Immunohistochemistry was used to positively identify subpopulations of fibers expressing only the 2B MHC.
To determine a character of muscle fibers (type II or type I) exhibiting changes in p27 expression, adjacent cryostat sections were stained for actomyosin adenosinetriphosphatase (ATPase).
Identification of I and IIa fibers by immunohistochemistry was fully concordant with identification of these fiber types by the myofibrillar actomyosin ATPase histochemical staining procedure.
Caldesmon is likely to play a modulatory role on the production of smooth muscle force via a tethering of actin to myosin [ 11 ] and/or of its effects on the actomyosin ATPase [ 12 13 14 ] . Similarly, TM does not seem to function as a major regulatory protein, but modulatory effects due to its ability to maintain the actin filamentous structure [ 15 ] , to inhibit the Ca 2+-ATPase activity [ 16 ] , alter the cytoskeletal dynamics [ 17 ] and improve actin filament flexibility during the contraction/relaxation cycle [ 18 19 ] have been well documented.
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