Example sentences for: accrue

How can you use “accrue” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The myofiber somehow “remembers” not only the pattern of activity it has experienced today, but what has gone on over the preceding days or weeks, such that the changes in abundance of proteins that control contractile function and metabolism accrue over time.

  • Employees can accrue savings by such means as using frequent flyer miles to obtain free airline tickets, sharing hotel rooms with coworkers, or staying with friends or relatives.

  • Approaches using aggregation adapt well to the dynamics of collaborative groups which are focused on sharing results as they accrue; examples are the University of California Santa Cruz (UCSC) genome browser [ 3] and the Distributed Annotation System (DAS) [ 4].

  • Even if these findings are not confirmed after further study, one could still make a compelling argument that lipid-lowering therapy (barring contraindications) should be initiated early and universally in patients who present with an acute coronary syndrome: First, the long-term safety and effectiveness of statins for the secondary prevention of stable coronary disease is well-established [ 1 2 3 ] ; Second, as evidenced by MIRACL, these agents are safe when initiated at the time of hospitalization for an acute coronary syndrome; Third, the in-hospital initiation of lipid-lowering therapy appears to promote greater long-term utilization of these agents [ 18 19 20 21 ] . Finally, although lipid levels may be unreliable in the setting of an acute coronary syndrome (excepting total :HDL and LDL:HDL cholesterol ratios [ 22 ] ) the overwhelming majority of patients with coronary disease will ultimately require both pharmacologic and non-pharmacologic lipid-lowering interventions to attain recommended cholesterol targets [ 23 24 25 ] ; newer guidelines are even more stringent [ 26 ] . Furthermore, data from the recently presented Heart Protection Study suggest that clinical benefits may accrue independent of baseline cholesterol level [ 4 ] . Thus, to withhold lipid-lowering therapy from patients who present with an acute coronary syndrome would be to accept the status quo, and to date our efforts at cholesterol lowering in the secondary prevention setting have been dismal [ 27 28 ] .

  • If benefits accrue, but do so later during follow up, it would be difficult to discriminate between the effects of more aggressive vs. earlier lipid lowering therapy.


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