Example sentences for: abnormality

How can you use “abnormality” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Hypokalemia and many types of electrocardiographic (ECG) abnormality are observed during the acute phase of subarachnoid hemorrhage (SAH) [ 1 2 3 ] . Among ECG abnormalities, a prolongation of the QT interval, especially when associated with hypokalemia, deserves particular attention because it is frequently observed in those patients who develop life-threatening ventricular arrhythmias such as tor-sades de pointes [ 1 2 4 ] . However, the pathogeneses of these abnormalities during the acute phase of SAH have not yet been fully investigated.

  • Atrial fibrillation segregates as an autosomal dominant disease characterized by atrial fibrillation on an electrocardiogram [ 1 ] . We diagnosed atrial fibrillation in five families from Spain in which the arrhythmia was the primary manifestation and not associated with any gross cardiac or metabolic abnormality [ 1 ] . Genetic linkage analysis was performed and the locus responsible for atrial fibrillation in our family was mapped to 10q22 between markers D101786 and D10S1630, an area of about 11 cM [ 1 ] . We proceeded with the candidate gene approach and DLG5 was on of the genes mapped to the critical region between the flanking markers [ 2 ] . This gene belongs to the MAGUK (Membrane Associated Gyanylate Kinase) family of proteins known to form scaffolds for proteins involved in intracellular signal transduction [ 2 ] . The MAGUK family of proteins has been extensively studied in recent years and shown to play a role in the formation of cell junctions, maintenance of cell shape, [ 3 4 5 ] and clustering of channel proteins at the cell surface [ 6 7 8 ] . Given its location in our critical region and its function it was selected as a candidate for atrial fibrillation.

  • The first factor is believed to cause the disorder and is most likely a structural or functional central nervous system (CNS) abnormality, whereas the second factor reinforces the first one, especially through avoidance learning.

  • An important question is whether the increase in cytoplasmic p27 expression correlates with the age of the patients and the severity of the muscle abnormality.

  • Here we show for the first time that the ERα protein is expressed in normal and marginally abnormal placentae (normal placental types) but barely detectable in placentae exhibiting moderate and severe abnormality (abnormal placental types).


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