Words similar to abcg
Example sentences for: abcg
How can you use “abcg” in a sentence? Here are some example sentences to help you improve your vocabulary:
Abcg8 . However, only one non-synonymous nucleotide change, G1754T, resulting in a conservative cysteine substitution for glycine at amino acid 583 (Gly583Cys) in sterolin-1 was identified (Fig.
ABCG5 and ABCG8 are two genes located adjacently in a head-to-head configuration on human chromosome 2p21, encoding for two half-transporters, sterolin 1 and sterolin 2 respectively [ 9 10 12 ] . Mutations in either of these genes causes sitosterolemia, characterized by hyperabsorption of phytosterols, reduced excretion of sterols into the bile and very elevated levels of plasma plant sterol levels.
Additionally, while screening an enterocyte cDNA library for full length cDNAs using PCR, we consistently amplified two DNA products when using Abcg8 primers flanking exon 2; one of the expected size, and another very low copy product ~60 bases larger.
However, a literature search revealed that a few strains of rats, studied primarily for investigation of hypertension and stroke, have been reported to be sitosterolemic as well [ 15 16 ] . We hypothesised that these rat strains may be mutated in either Abcg5 or Abcg8 . Tissue (and plasma) plant sterol levels in the Wistar Kyoto (WKY) rat, the spontaneously hypertensive rat (SHR) and the stroke-prone spontaneously hypertensive rat (SHRSP) were significantly higher than in Wistar and WKA rats fed either a regular chow diet or diets that have higher plant sterols and these were correlated with increased death, or red cell hemolysis etc. [ 15 16 17 18 19 20 21 22 ] . Dietary sterol absorption rates were increased, with a decrease in sterol excretion [ 16 ] , characteristics similar to that observed in sitosterolemic patients.
Using a more sensitive RT-PCR analyses of RNA obtained from different tissues confirmed that rat Abcg5 and Abcg8 genes were expressed in both in the liver and small intestine, with a low level of expression in the colon (Fig.
Loading...