Example sentences for: abacavir

How can you use “abacavir” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Amprenavir (APV) is a potent protease inhibitor (PI) that is used in combination with other antiretroviral drugs for the treatment of antiretroviral-naïve and -experienced adults and children with HIV infection [ 1 2 3 4 5 ] . APV offers the convenience of twice-daily (BID) administration with no food or fluid restrictions [ 6 7 ] . Preclinical and clinical data suggest that APV has a lower potential to cause lipodystrophy and metabolic abnormalities than other currently available PIs [ 8 9 10 ] . APV has a distinct resistance profile that permits it to be considered as a treatment option for either PI-naïve or PI-experienced patients [ 11 ] . In a 64-week trial in treatment-naïve patients (NZTA4002; n = 302), APV 1200 mg, administered BID (APV1200) with one abacavir 300 mg tablet and one lamivudine 150 mg/zidovudine 300 mg combination tablet (Combivir ®), was as effective as nelfinavir 750 mg three times daily plus Combivir BID, with regard to the proportion of patients achieving HIV-1 RNA <40 copies/mL at week 64: 77% vs 66% (as-treated analysis) [ 12 ] . However, many patients in this trial withdrew prematurely because of adverse events that may have been, in part, related to the high pill burden (16 large 150 mg soft-gelatin capsules daily) associated with APV dosing and excipients contained in the APV formulation available at the time of the trial.

  • The most common background antiretroviral regimens taken by patients in the APV600/RTV and APV1200 treatment arms were stavudine/didanosine (25% vs 30%), Combivir (19% for both arms), abacavir/stavudine (11% for both arms), lamivudine/stavudine (9% vs 4%), and abacavir/didanosine (5% vs 6%).

  • In another study of APV600/RTV in antiretroviral-naïve patients, Arasteh et al [ 19 ] reported a higher proportion of patients achieving plasma HIV-1 RNA <50 copies/mL (75%) than in the present study, perhaps due to the use of only lamivudine and abacavir as background antiretroviral medication and to differences in their study population relative to ours.


How many words do you know? Try our free vocabulary size test!


Search

Search for example sentences

Loading Loading...
Quantcast