Words similar to prostatic
Example sentences for: prostatic
How can you use “prostatic” in a sentence? Here are some example sentences to help you improve your vocabulary:
Mutations in the IL-6 promoter region may play a role in the tumorigenic effects of constitutive IL-6 expression in prostatic carcinoma cells [ 33 ] . Such polymorphisms have been described for the IL-6 receptor in Kaposi's sarcoma, and are believed to play a role in IL-6-mediated progression of this type of cancer [ 32 ] .
The exquisite sensitivity of prostatic epithelial cells to androgens has been exploited therapeutically in the management of prostate cancer [ 4].
Choline, sorbitol, amino acids and citrate are also found in the prostatic secretions, although only a few genes (for sorbitol dehy-drogenase, phosphatidylcholine transfer protein, amino-acid transporter) related to these pathways appeared to respond directly to androgen.
For example, viral IL-6 might be incorporated into the genomes of prostatic carcinomas, as has been described for Kaposi sarcoma [ 5 32 33 39 40 41 ] . The route of introduction of the viral IL-6 is believed to be through previous herpesvirus infection [ 39 41 ] . Another possibility is that the insertion of the oncogene BRCA1 results in the constitutive activation of STAT3 in NRP-154 cells, as has been described in Du-145 prostate cancer cells [ 42 ] . Du-145 cells do not make IL-6; nor are they dependent upon it for continued proliferation in vitro.
Further investigation into androgen-induced changes in gene and protein expression in vitro and in vivo will undoubtedly shed light on prostatic physiology and prostatic carcinoma, and also on broader physiological functions of androgen.
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