Example sentences for: paracrine

How can you use “paracrine” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • [ 22 ] showed that SCYA17 potentially played a role via a paracrine mechanism in the development of allergic respiratory diseases.

  • The concept of lung fibroblasts as effector cells in the pathogenesis of idiopathic pulmonary fibrosis (IPF) has recently evolved [ 1 2 ] . Lung fibroblasts respond, in vitro , to inflammatory cytokines by producing growth factors and collagen, resulting in fibroblast proliferation and extracellular matrix deposition [ 2 3 4 ] . In addition, activated lung fibroblasts have been shown to produce large amounts of inflammatory cytokines and chemokines, in vitro , and hence, these cells may also have a role as effector-inflammatory cells [ 1 2 ] . This capacity to produce both inflammatory and fibrotic factors could mean that phenotypically altered lung fibroblasts act simultaneously as effector and target cells, via paracrine and autocrine mechanisms, perpetuating the fibrotic process [ 2 ] .

  • They may represent a unique paracrine mechanism, so called "targeted delivery," by which certain growth factor (vesicle content) is delivered by chemotaxis to certain type/stage specific target cells expressing receptor for Thy-1 ligand.

  • These peptides are released into the central circulation and may act systemically, as opposed to many of the known mediators of sepsis, which are released locally and often act in an autocrine or paracrine fashion.

  • OPG is currently hypothesized to be an important paracrine mediator of the antiresorptive action of estrogen on bone cells [ 25].


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