Example sentences for: papain-like

How can you use “papain-like” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The NlpC/P60 domain is predicted to adopt a papain-like fold, in which the catalytic cysteine is at the amino terminus of a helix, which is packed against a five-stranded β-barrel with the histidine and the polar residue.

  • Such substitutions have previously been observed in other papain-like peptidases with the serine participating in a functional active site [ 61, 62].

  • The configuration, comprising a catalytic cysteine at the amino terminus of a helix packed against a core three-stranded β-sheet, with the second and third strands bearing the catalytic histidine and its orienting polar partner, is seen in the transglutaminases and a related class of amino-group acetyltransferases, papain-like proteases, adenoviral proteases and ubiquitin carboxy-terminal hydrolases [ 32, 38] (Figure 2).

  • In the case of papain-like proteases - calpains, transglutaminases and NH 2 -acetyltransferases - the three-stranded sheet of the core is incorporated into β-barrel with five to eight constituent strands (Figure 2).

  • This suggests that despite the absence of significant sequence similarity, the NlpC/P60 domain is likely to contain a structural core corresponding to the classical papain-like protease fold (Figure 2).


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