Words similar to ocd
Example sentences for: ocd
How can you use “ocd” in a sentence? Here are some example sentences to help you improve your vocabulary:
In the present experiments, AVP-induced grooming and flank marking behaviors were tested in hamsters exposed to chronic treatment with psychotropic drugs shown in preclinical and clinical studies to be effective in the treatment of OCD [ 20 28 ] . The results show differential responsiveness to these treatments.
This pattern of responsiveness to drug treatment suggests that AVP-induced flank marking may be used as a model for screening psychotropics used in the treatment of OCD.
For example, chronic treatment with fluoxetine decreases the release of AVP from rat hypothalamic organ cultures [ 36 ] . This finding is particularly noteworthy since alterations in AVP levels in the cerebrospinal fluid have been correlated with occurrences of OCD [ 15 16 ] . The occurrence of OCD has also been correlated with increased levels of oxytocin, a neuropeptide closely related to AVP [ 37 ] . In golden hamsters, the elevation of serotonin in the anterior hypothalamus following fluoxetine treatment can inhibit the activity of the AVP system related to aggressive behavior [ 10 11 ] . The ability of microinjected AVP in the anterior hypothalamus to enhance aggressive behavior in golden hamsters is blocked by fluoxetine treatment and serotonin 5HT 1A receptor agonists [ 10 ] . The present data include AVP-stimulated flank marking in the list of behaviors suppressed by fluoxetine treatment.
The doses and treatment regimen for each drug were comparable to those used in several preclinical studies examining the pharmacological control of OCD [ 25 38 39 ] . Acute drug trials were not attempted as the experimental design followed that of previously published studies [ 25 38 39 ] . After 2 weeks of treatment, hamsters were tested for flank marking after a microinjection of AVP (10 μM in 100 nl saline).
Future studies could focus on effects of long-term elevation of AVP in hamsters; dose-response manipulations of psychotropics or clinical use of AVP receptor antagonists on humans to further investigate the role of AVP in OCD.
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