Words similar to ipf
Example sentences for: ipf
How can you use “ipf” in a sentence? Here are some example sentences to help you improve your vocabulary:
We have found that fibroblasts cultured from normal and IPF human lungs have a significant and similar induction of the COX-2 enzyme when stimulated with IL-1β, but that IPF fibroblasts produced more thromboxane and had a significantly lower prostacyclin:thromboxane ratio.
TXA 2 production tended to be greater in IPF than in normal fibroblasts at baseline; when stimulated with IL-1β this difference became statistically significant.
We hypothesize that the lower PGI 2 :TXA 2 ratio seen in HF-IPF may be a phenotypic alteration that plays a role in the pathogenesis of IPF.
Recent reports suggesting decreased COX-2 expression and PGE 2 production in IPF fibroblasts have received significant attention [ 12 20 21 ] . In our study we found that both COX-2 protein expression and PGE 2 production were upregulated to a similar degree in IPF and normal lung fibroblasts.
Although the reasons for our different results are unclear, the fact that we found similar COX-2 expression and PGE 2 production in normal and IPF lung fibroblasts suggests that loss of COX-2 expression is not a universal characteristic of fibroblasts cultured from the lungs of subjects with IPF.