Words similar to igfs

Example sentences for: igfs

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In addition, choroid plexus expresses insulin, IGF-I, and IGF-II receptors [ 11 47 ] ., as well as large amounts of IGF-II that is secreted into the CSF [ 47 ] . CSF contains insulin/IGFs and 5-HT [ 48 ] in concentrations high enough to activate their respective receptors in choroid plexus, suggesting that this signaling mechanism may occur in vivo . It has been suggested that 5-5HT 2C receptors in choroid plexus may be tonically activated, due to CSF 5-HT concentrations near the EC 50 , thus tonically inhibiting CSF production.
Numerous studies have shown that polypeptide growth factors such as insulin-like growth factors (IGFs) are mitogens for breast cancer cells [ 6 7 8 9 ] . The IGF-I and IGF-II signal through a common tyrosine kinase receptor, the insulin-like growth factor 1 receptor (IGF1R), and have mitogenic and cell survival actions that may promote tumor development.