Example sentences for: deleterious

How can you use “deleterious” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • [ 1 ] ). By contrast, if deleterious mutations interact so that their combined effect is smaller than expected under the multiplicative model, then epistasis is called antagonistic (or positive in the terminology of Phillips et al.)

  • The plasminogen activators, tissue type and urokinase type, have been reported to be both deleterious in inflammation, owing to the proteolysis of tissue proteins, and beneficial because of fibrinolytic activity [ 26 ] . The presence of both increased urokinase and plasmin inhibitors in rheumatoid arthritis synovial tissue suggests a complex role for urokinase in this disease [ 27 28 29 ] that seems pertinent to our finding of urokinase-generated mactinin in the arthritis fluid samples.

  • The trajectory for mean fitness as random mutations accumulate is generally one of decay because many more mutations are deleterious than are beneficial.

  • By increasing the rate at which deleterious mutations appear, APOBEC3G pushes viruses over this edge, causing a form of ‘lethal mutagenesis’ that results in their destruction; the rate of mutation becomes so high that no genome can reproduce itself faithfully, and the population crashes.

  • An additional argument for calling all these mutations compensatory is that they can produce a fitness gain only in association with one or more mutations that would otherwise be deleterious, that is, none of the mutations that could be termed advantageous is accessible directly from the main neutral network.


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