Words similar to deferiprone
Example sentences for: deferiprone
How can you use “deferiprone” in a sentence? Here are some example sentences to help you improve your vocabulary:
In the first study, 144 patients with thalassemia major and relatively low serum ferritin concentrations (1,500 - 3,000 ng/mL) were randomized to either deferiprone (n = 71) or desferrioxamine (n = 73) and followed for one year [ 28 ] . Although, the primary efficacy measure was the reduction of serum ferritin, HIC was assessed in a small subgroup of patients willing to undergo repeat liver biopsy: 21 in the deferiprone and 15 in the desferrioxamine group.
A case-control study in 15 patients treated with deferiprone (cases) and 30 patients treated with desferrioxamine (controls) matched for age and serum ferritin levels, demonstrated that deferiprone appears to be more effective than desferrioxamine in removal of myocardial iron despite significantly higher HIC in the deferiprone group [ 5 ] . Although a larger prospective trial is needed to confirm the results, these findings would suggest that a combination of both drugs may be most beneficial in order to reduce both hepatic and myocardial concentrations of iron.
On the other hand, the results from the only randomized trial suggest that even at relatively low doses, desferrioxamine outperforms deferiprone [ 11 ] . Moreover, the toxic:therapeutic ratio of deferiprone is reportedly low; doses of 100 mg/kg/day have resulted in bone marrow toxicity in animals and humans.
All studies of desferrioxamine and deferiprone usage in thalassemia major patients - whether randomized, blinded, comparative, case series, or cross-over - irrespective of language were considered eligible for inclusion in the analysis.
For deferiprone, the corresponding threshold was 75 mg/kg/day.
Loading...