Words similar to beta-catenin

Example sentences for: beta-catenin

How can you use “beta-catenin” in a sentence? Here are some example sentences to help you improve your vocabulary:

A recent report demonstrated that Wnt-5a and Rfz-2 can induce the nuclear localization of the transcription factor NF-AT [ 14 ] . Their results show that NF-AT is a downstream target of the Wnt/Ca 2+pathway and antagonizes the Wnt/beta-catenin pathway in Xenopus embryos.
Wnts in this functional class activate the canonical Wnt/beta-catenin pathway (Wnt-1, -3A, and -8).
, without co-expressing LRP5/6) preferentially activate the Wnt/beta-catenin or Wnt/Ca 2+pathways [ 5 ] . Interestingly, Wnt-5a may couple to either pathway depending on which frizzled receptor is present.
Beta-catenin then accumulates in the nucleus where it interacts with its transcriptional co-activators, members of the Lymphoid Enhancer Factor/T Cell Factor (LEF/TCF) family of high mobility group DNA binding proteins to regulate gene expression [ 1 ] . Many downstream gene targets of the canonical Wnt/beta-catenin pathway have been identified http://www.stke.org.
LiCl has previously been shown to mimic activation of Wnt-1 signaling by stabilizing beta-catenin through its inhibition of glycogen synthase kinase-3β (GSK-3β), a kinase that phosphorylates beta-catenin and promotes its degradation via the ubiquitin proteasome pathway [ 39 ] . C57mg cells treated with LiCl exhibited elevated levels of mesothelin but not SL-1 (Figure 2, left panel).