Example sentences for: axin

How can you use “axin” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • If the carboxyterminus of LRP6 can interact with Axin independently of DFz2 and Dsh, it might reduce the cytoplasmic level of Axin and help stabilize β-catenin.

  • In agreement with this possibility, an intracellular domain of LRP5 was reported to interact directly with Axin [ 13 ] , and Wnt signaling appears to stimulate the recruitment of Axin to LRP5 at the membrane, where Axin is degraded.

  • These results are consistent with claims that LRPs can signal through an interaction of the carboxyterminus with Axin [ 13 ] .

  • While the functions of Fz and Dsh remain to be clarified, it is possible that upon Wnt signaling, Fzs recruit Dsh to the membrane and Dsh brings Axin to the carboxyterminus of LRPs.

  • Similar results were reported for this FLAG epitope-tagged mutant in other cell lines [ 26 ] . Second, the tail kinking and "waltzing" phenotypes in our transgenic animals expressing stabilized human β-catenin are highly similar to those seen in Fused mice [ 29 ] . Fused encodes the murine Axin homologue, and mutation of this gene results in activation of Wnt signaling [ 30 ] . The tail kinking in our animals presumably results from low level expression of the mutant transgene in utero during vertebral patterning.


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