Example sentences for: acv

How can you use “acv” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • [ 10 ] . Plating efficiency assays were performed in MRC-5 cells at 3 μg/ml ACV, which is 10-times higher than the average IC 50 for HSV-1 SVC16, and at 8 μg/ml ACV, which is 10-times higher than the average IC 50 for the panel of HSV-2 viruses.

  • These results were confirmed when the same isolates were tested for susceptibility to ACV (results not shown) and all the IC 50 s were sensitive over a similar range as PCV.

  • This result appears to be in direct contrast to that of Field [ 9 ] who found that following selection of ACV-resistant virus in vivo, such viruses remained refractory to treatment upon subsequent passage using suboptimal treatment with ACV.

  • The natural phenomenon of spontaneous mutation, which occurs in the absence of drug selection, results in the accumulation of approximately six to eight TK-deficient variants per 10 4plaque-forming viruses in virus populations that have never been exposed to selective pressure [ 6 10 12 ] . Furthermore, HSV-2 clinical isolates were shown to have a higher frequency of spontaneous mutations resistant to ACV and PCV, approximately 30-fold, compared to HSV-1 isolates, and the majority of these mutations are in tk . Consistent with this observation, HSV-2 strains also exhibited approximately a 20- to 80-fold higher spontaneous mutation rate to cidofovir (HPMPC), an inhibitor of HSV Pol, resistance compared with HSV-1 [ 21 ] . Therefore, these naturally-occuring mutations are not unique to tk and TK substrates as detected with antiviral agents ACV and PCV, but were extended with the direct Pol inhibitor, HPMPC, to other loci, most likely pol .

  • Sub-optimal therapy of immunocompetent mice with either VCV or FCV did not readily select for HSV-mutants resistant to either ACV or PCV, suggesting that selection of resistance with either prodrug remains difficult using this system.


How many words do you know? Try our free vocabulary size test!


Search

Search for example sentences

Loading Loading...
Quantcast