Example sentences for: peptide-specific

How can you use “peptide-specific” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Therefore, optimized use of heteroclitic peptide to induce an initial peptide-specific T cell response, followed by selective expansion of the highest RE tumor-lytic T cells may be needed for an effective strategy with clear clinical application.

  • For isolation and detection of peptide-specific T cells, patient PBMC samples were stained and analyzed by fluorescence-activated cell sorting (FACS) as previously described [2].

  • In our system, we cannot distinguish if the amino acid change we have created has its effects on binding to the guinea pig MHC, interaction with the T cell receptor, or more efficient processing of the epitope from the protein precursor [ 51 ] . Any or all of these mechanisms could contribute to the enrichment for peptide-specific proliferative responses seen in vitro.

  • The samples from these six patient had peptide-specific T cell populations detectable with G209–2M-tetramers (patients 422, 476, and 132) or M26-tetramers (patients 517, 520, and 461) ranging from 0.1% to 2.5% of total CD8+ T cells (Figure 1A).

  • In recent cancer vaccine trials [3,4,5], many melanoma patients who received heteroclitic peptide vaccines gp100 209–217 (210M) (IMDQVPSFV; G209–2M) and MART 26–35 (27L) (ELAGIGILTV; M26) had measurable CD8+ peptide-specific T cell responses in PBMCs detected by peptide–MHC tetramer staining.

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