Example sentences for: penetrance

How can you use “penetrance” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Penetrance is defined as the probability of diseasegiven a particular combination of genotypes.

  • Lod scores were calculated using the Fastlink version 3.0 package of programs [ 27 ] , assuming autosomal dominant inheritance with complete penetrance, and a disease incidence of 1 in 1,000,000 births, as described previously [ 7 8 ] . Because of the absence of specific allele frequencies for each of the ethnic groups represented in the study, we assumed ten marker alleles of equal frequency.

  • Genetic counseling for patients and family members should always accompany genetic testing as variable expressivity and age dependent penetrance may influence clinical decision making [ 25 ] .

  • For this model, the high-risk genotypecombinations are AAbb , AaBb , and aaBB withdisease penetrance of 0.1, 0.05, and 0.1 respectively.

  • MAdCAM-1 is normally expressed in the gut, and its expression is dramatically amplified during inflammation [ 2 3 ] . The functional significance of increased appearance of MAdCAM-1 in IBD is supported by several reports which show that immunoneutralization of either MAdCAM-1 or its ligand, the α4β7 integrin, attenuate inflammation and mucosal damage in animal models of colitis [ 8 9 10 ] . However, since monoclonal antibodies directed against other ECAMs, particularly VCAM-1, can as well reduce disease activity in colitis models [ 11 12 13 14 ] , the literature suggests that MAdCAM-1 is probably necessary, but insufficient for the maximal penetrance of experimental and probably also clinical IBD.


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