Example sentences for: penetrance

How can you use “penetrance” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The penetrance and severity of anterior and posterior segment phenotypes was strongly influenced by genetic background (Table 1).

  • The localization of genes in complex genetic diseases is a challenging proposition, given that these disorders are likely to show significant locus heterogeneity, genetic epistasis, and incomplete penetrance, as well as environmental effects.

  • MAdCAM-1 is normally expressed in the gut, and its expression is dramatically amplified during inflammation [ 2 3 ] . The functional significance of increased appearance of MAdCAM-1 in IBD is supported by several reports which show that immunoneutralization of either MAdCAM-1 or its ligand, the α4β7 integrin, attenuate inflammation and mucosal damage in animal models of colitis [ 8 9 10 ] . However, since monoclonal antibodies directed against other ECAMs, particularly VCAM-1, can as well reduce disease activity in colitis models [ 11 12 13 14 ] , the literature suggests that MAdCAM-1 is probably necessary, but insufficient for the maximal penetrance of experimental and probably also clinical IBD.

  • The high-risk genotype combinations are AaBB , Aabb , AABb ,and aaBb with disease penetrance of 0.1 for all four.

  • This could be the result of variation in the penetrance of the mutation.

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