Words similar to pedigrees
Example sentences for: pedigrees
How can you use “pedigrees” in a sentence? Here are some example sentences to help you improve your vocabulary:
Eleven of the 20 pedigrees are large enough to establish linkage to a specific locus; we previously reported that the CFEOM1 phenotype in 9 of these pedigrees maps to the FEOM1 locus [ 6 15 25 26 ] and we now demonstrate that the remaining two also map to FEOM1.
Evidence that genetic factors play a role in some cases of premature ovarian failure has been around for a long time [ 19 20 ] . However, the small pedigrees necessarily associated with this condition make it extremely difficult to conduct genetic linkage analysis that can be used to identify candidate genes.
Model-dependent linkage analysis has been used in large pedigrees with diseases such as cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) [ 6 7 8 9 ] . However, traditional linkage analysis is unlikely to be the most expedient method of finding novel stroke-susceptibility genes when carrier status cannot be defined on the basis of distinctive clinical, radiographic, or laboratory features.
In our attempt to understand phenotype-genotype correlations between specific CFEOM phenotypes and FEOM loci, we noted that the CFEOM1 phenotype in all pedigrees reported to date maps to the FEOM1 locus.
In contrast to the 18 pedigrees whose CFEOM1 phenotype is consistent with linkage to FEOM1, pedigree BT is not linked to FEOM1 and pedigree K is inconsistent with linkage to this locus.