Example sentences for: pedf

How can you use “pedf” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The PEDF-heparin/HS complex may somehow facilitate encounters between PEDF and its receptor, e.g. , by inducing a conformational change in PEDF, which might accelerate the ligand-receptor interactions.

  • Biochemically, PEDF is a 50-kDa glycoprotein with structural homology to members of the serine-protease inhibitor (serpin) superfamily [ 3 15 ] . However, it has no inhibitory effects on proteases.

  • Finally, the fact that the GAG and receptor binding regions are on opposite regions of the PEDF molecule, suggest the possibility of the existence of PEDF mutants or engineered variants that, having lost or decreased GAG-binding capabilities, still show high affinity for the PEDF receptor in a way not dependent upon GAGs content or composition.

  • To determine whether PEDF interacts with component(s) in media conditioned by retinoblastoma cells (CM), we used an ultrafiltration assay.

  • Cell-associated HS proteoglycans can undergo regulated shedding from the membrane into the soluble extracellular matrix or culturing medium converting the membrane anchored molecules into soluble effectors [ 1 2 ] . In the conditioned media of all the tested batches of retinoblastoma cells, we detected heparin and HS with binding affinity for PEDF.


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