Example sentences for: peaking

How can you use “peaking” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Over the 24 weeks of the study, the median CD4+ cell count remained higher than baseline, with median elevations above baseline peaking at week 12 in both treatment arms (+51 and +52 cells/mm 3, respectively) (Figure 3).

  • Analysis of monocytic TTP showed an increase in expression, peaking at 2 hours (Fig.

  • Among genes that are stimulated by FSH/cAMP during the period of maturation of Sertoli cells (15 to 20 days of age in rats), are several subunits of cAMP-dependent protein kinase (PKA), the serine/threonine kinase mainly responsible for the downstream effects of FSH [ 15 ] . Expression of the RIIβ regulatory subunit of cAMP-dependent protein kinase is highly induced (50-fold) at the mRNA level in primary cultures of rat Sertoli cells as a late response to cAMP peaking at 12 hours [ 16 ] . We have demonstrated that expression of CAAT/Enhancer binding protein β (C/EBPβ) is induced by cAMP with rapid kinetics in Sertoli cells, and that C/EBPβ is responsible for induction of late response genes like the RIIβ-gene [ 17 ] . The RIIβ promoter contains a conserved E-box/HLH element in the basal promoter localized at -280 to -275 relative to the functional ATG [ 18 ] . This element is shown to be important for cAMP-responsiveness in granulosa cells, and it has been shown to bind both USF and Myc in CHO and NB2a cells [ 18 19 ] . In this work, we show that USF isoforms may regulate cAMP responsiveness of the RIIβ promoter by modulating the effect of C/EBP, and that the formation of USF isoforms may be regulated by cAMP in Sertoli cells.

  • Several pundits note that Bradley may be peaking early and that Moynihan also endorsed Bob Kerry in 1992 and Ted Kennedy in 1980 (Mara Liasson, Fox ; Margaret Carlson, Capital Gang ).

  • Data shown in Figure 4Bindicates that induction of luciferase activity in tumor xenografts is prompt, peaking between 6-12 hours.


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