Example sentences for: pdgf

How can you use “pdgf” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Thus, the adhesion of RASMCs to III1-C resulted in robust activation of ERK1/2 that was comparable to the activation obtained with PDGF.

  • The whole cell extracts were prepared and used for Western blot with anti-PDGF receptor α using RIPA buffer containing SDS.

  • We would like to see if PDGF receptor expression in lung cancer patients is frequent finding, and this could potentially provide a cellular mechanism by which Gleevec inhibits the lung cancer tumor growth.

  • Gleevec has been demonstrated to inhibit the growth and proliferation of GIST, and induce complete or partial clinical remission in GIST patients [ 6 7 ] . Recently Gleevec was showed to inhibit the growth of dermatofibrosarcma protuberans (DFSP) through inhibiting the PDGF receptor [ 8 9 ] .

  • Gleevec has been shown to induce clinical, hematological and molecular remissions for CML patients [ 4 ] . It cross-reacts with two other important growth factor receptors containing tyrosine kinase domains, c-kit and PDGF receptors, that play important roles in growth and proliferation of a variety of cell types [ 5 ] . C-kit (also known as CD117) is frequently mutated in gastrointestinal stromal tumor (GIST), and the mutated c-kit shows higher tyrosine kinase activity.


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