Example sentences for: pcaf

How can you use “pcaf” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The p160s enhance transcription by binding histone acetyl-transferases such as p300/CBP and pCAF [ 5 ] and methyl-transferases such as CARM1 and PRMT [ 6 ] which, in turn, enhance transcription by modification of chromatin.

  • [ 18 ] . This constitutively activated Stat3 (a mutant produced by substitution of the cysteine residues within the COOH-terminal loop of the SH2 domain of Stat3) induces cellular transformation and tumor formation in nude mice [ 18 ] . The plasmids to express other coactivators (SRC-1, CBP/p300, TIF2 and PCAF) have been described elsewhere [ 29 30 ] .

  • PCAF, p300/CBP associated factor

  • RNA polymerase II (pol II) transcription factor TFIID comprises the TATA-binding protein (TBP) and a set of TBP-associated factors (TAF II s) [ [ 1 2 3 ] ]. At least 12 TAF II s have been identified in TFIID and cloning of their cDNAs has shown an evolutionary conservation of TAF II s from yeast to mammals [ [ 4 5 6 7 ] ]. TAF II s are not only components of the TFIID complex, but a subset of TAF II s are also found in the SAGA, PCAF, TFTC/STAGA complexes which lack TBP [ [ 8 9 10 11 12 ] ].

  • The RARα amino terminus is not known to interact with CBP or its associated factor PCAF [ 5 18 ] . Additionally, RARs bind to the interaction domains of repressor proteins such as NCoR via region D of the receptor rather than the amino terminus [ 4 ] . Despite the lack of obvious interaction of the RAR amino terminus with nuclear receptor cofactors, the S77A mutation may alter the three dimensional structure of the receptor.


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