Example sentences for: pathophysiologic

How can you use “pathophysiologic” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Because the expression of COX-2 is associated with key pathophysiologic event(s) in Alzheimer's disease [ 53 54 55 ] , the significant increase in COX-2 expression in the frontal cortex may be relevant to the cognitive decline seen in the Phyto-600 males.

  • Of note, these experiments were performed using a total fatty acid:BSA ratio of 6.6:1, in order to closely model pathophysiologic states in which unbound FFA concentration is high [27].

  • The available research regarding cognitive function and phytoestrogens suggests that large amounts of phytoestrogens, consumed as tofu, have an adverse influence on cognitive ability in men, where decreased brain weight, increased ventricular size and dementia have been reported [ 44 ] . In ovariectomized female rats, on the other hand, phytoestrogen treatments resulted in a dose-dependent improvement of VSM [ 45 ] . This improvement in cognitive ability in phytoestrogen treated females may be due in part to the increased presence of choline acetyltransferase messenger RNA in the frontal cortex, which has been shown to be associated with protection and enhancement of cognitive function [ 45 ] . Furthermore, we have shown that phytoestrogens significantly affect the brain calcium-binding protein calbindin (CALB), which acts as a buffer by binding intracellular calcium and plays an important role in mediating cell proliferation, programmed cell death (apoptosis), and neurotoxicity [ 48 49 50 51 52 ] . This neuroprotective mechanism via CALB appears to be important in neurological disorders such as Parkinson's disease and Huntington's disease [ 48 49 50 51 52 ] . Additionally, Cyclooxygenase-2 (COX-2) seems to play an important role in mediating functional neuronal maturation and responses to certain stimuli in the brain [ 53 54 55 ] . The expression of COX-2 is associated with key pathophysiologic events in Alzheimer's disease: deposition of beta-amyloid protein in neuritic plaques within the hippocampus and cortex [ 53 54 55 ] . Of particular importance to this study is the fact that COX-2 has been shown to be influenced by steroidal hormones [ 53 54 55 ] . Therefore, the expression of COX-2 in the frontal cortex may also be hormonally regulated and relevant to cognitive decline.

  • Failure to consider the underlying pathophysiologic mechanism when searching for polymorphisms associated with stroke might result in mistaking association for causation [ 2 ] . We studied genes related to thrombosis because the importance of thrombosis in acute ischemic stroke has been established conclusively in numerous clinical trials of treatment and prevention [ 3 4 5 6 7 8 ] . We focused on genetic variations in the fibrinogen gene cluster because of the efficacy of fibrinolytic agents in the acute treatment of ischemic stroke.

  • Although speculative, it is tempting to propose that HPT and HGEC may be early targets of Stx-1 and that this could play a role in the pathophysiologic processes that characterize renal injury in HUS.


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