Example sentences for: pathologic

How can you use “pathologic” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Pathologic classification of tumors has been traditionally based on microscopic appearance.

  • It has been suggested in several papers that changes in sympathetic nervous system responsiveness may begin as a positive adaptation, but ultimately results in pathologic failure of the myocardium.

  • Fourth, MeCP2 action on chromatin, as suggested by observed changes in histone acetylation [ 31 32 ] , may not involve protein coding genes that are represented on microarrays, but instead, may affect centromeric heterochromatin or the expression of small non-coding RNAs that are abundant in normal brain [ 33 ] . The results presented in this paper contradict the established model of MeCP2 function and necessitate a rethinking of strategies to unravel the pathologic process that leads to neuronal dysfunction in Rett syndrome.

  • Activation of this pathologic process is complex, most likely involving the activation or repression of numerous signal/transduction pathways, with subsequent effects on many genes.

  • Previously reported microarray studies of female Rett and unrelated control brain samples revealed expression changes that were interpreted as secondary to the disease process, such as increased expression of glial-specific genes and decreased expression of neuronal genes [ 25 ] . Therefore, when searching for the primary targets of MeCP2 modulation, it might be advantageous to study a tissue that is less obviously involved in the pathologic processes of the disease.


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