Example sentences for: pathogenicity

How can you use “pathogenicity” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The inability to detect sterilizing immunity in high-dose challenge experiments led to a shift of focus towards indirect effects of vaccine candidates on the pathogenicity of the infection and the infectiousness of the vaccinee.

  • Closer analysis of the cag pathogenicity island revealed that the predictions were for the most part identical to the previously published predictions.

  • Resistance to acyclovir (ACV) or penciclovir (PCV) generally arises by a single base mutation in either the HSV thymidine kinase (TK) or DNA polymerase (Pol) gene [for a review, see reference [ 5 ] ]. Unlike Pol, TK is not essential for virus replication in cell culture [ 7 ] , although in vivo analyses implicate it in HSV virulence, pathogenicity and reactivation from latency [ 4 8 16 22 ] . Since ACV and PCV are dependent upon HSV TK for monophosphorylation, an event obligatory for the formation of the active triphosphate inhibitor [ 14 ] , ACV risolates often exhibit high levels of cross-resistance to PCV [ 2 3 ] .

  • Analysis of the cag pathogenicity island reveals that whereas the major differences are conserved, some loci also display consistent weak signal across a portion of the strains (black regions, Figure 9).

  • The in vivo pathogenicity of selected virus preparations was assessed in mice by monitoring lesion severity for 14 days following inoculation of the left ear pinna with 5 × 10 5PFU.


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