Example sentences for: pathogenesis

How can you use “pathogenesis” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • A strong candidate is TNF itself, as it encodes the potent pro-inflammatory cytokine TNF, and there is a significant body of clinical and experimental data suggesting a causal role for it in the pathogenesis of many of the diseases with which it has been associated.

  • Monocyte/macrophage infiltration has a key role in the pathogenesis of chronic arthritis [ 8 ] . The release of pro-inflammatory cytokines, chemokines, growth factors, and enzymes by the synovial lining macrophages is important for the onset, propagation, and flare of arthritic inflammation [ 9 ] . The finding that the number of synovial tissue macrophages is correlated with joint destruction in rheumatoid arthritis is evidence of their importance [ 9 10 ] . Monocytes and macrophages are believed to have a similar role in other chronic inflammatory joint diseases, such as gout [ 11 ] and psoriatic arthropathy [ 12 ] . Therefore in this study we assessed the effects of mactinin on monocyte chemotaxis in vitro . We have also tested synovial fluid from patients with various types of arthritis, including rheumatoid arthritis, psoriatic arthritis, reactive arthritis, gout, and ankylosing spondylitis, for the presence of the monocyte/macrophage maturation-promoting fragment, mactinin.

  • Although the role of CMV infection in pathogenesis of vascular diseases in immunocompetent patients is less clear, epidemiological studies strongly suggest that chronic or latent infections may accelerate the development of diseases such as atherosclerosis and SSc.

  • The proinflammatory cytokine TNF has been shown to play a role in the pathogenesis of RA [ 9, 10].

  • Clearly there is substantial controversy surrounding this locus and the A54T polymorphism in the pathogenesis of insulin resistance and T2DM as described above.


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