Example sentences for: pathogenesis

How can you use “pathogenesis” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The use of diuretics in the management of ARF remains controversial despite several advances in the understanding of the pathogenesis of renal failure and the mechanisms of action of the agents commonly used to manage it.

  • Long polyglutamine repeats have been found in a number of transcription factors [ 39 ] . Notably, the C-terminus of murine HMG-box protein SRY contains a large polyglutamine repeat region that is responsible for the sex-determining function of this protein [ 40 ] . However, a number of neurodegenerative disorders, such as Huntington disease and spinobulbar muscular atrophy, are also strongly associated with proteins containing a polyglutamine stretch [ 41 ] . Conformational change and protein misfolding in the expanded polyglutamine region is believed to be the molecular basis of the pathogenesis [ 42 ] . Whether the presence of polyglutamine repeats in the C-terminus of human TNRC9 is important for function or alternatively hinders its ability to form a functional protein remains to be determined.

  • T cells cause tissue injury through their secreted products such as cytokines; in mice, overexpression of interleukin (IL)-13, a T cell cytokine that is strongly implicated in the pathogenesis of experimental asthma, resulted in increased production of proteases and enlargement of airspaces reminiscent of emphysema [12].

  • Clearly there is substantial controversy surrounding this locus and the A54T polymorphism in the pathogenesis of insulin resistance and T2DM as described above.

  • Chronic inhalation of tobacco smoke causes progressive lung destruction in susceptible individuals, resulting in chronic obstructive pulmonary disease (COPD) and emphysema, two well-described clinical syndromes with poorly understood pathogenesis [1,2,3].


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