Example sentences for: pannus

How can you use “pannus” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Although both of these MMPs are expressed at the junction between synovial pannus and cartilage or bone [ 14], further evidence of their direct role in erosion formation is lacking.

  • The antigen-induced arthritis model of rheumatoid arthritis in rabbits demonstrates persistent active inflammation for several months after the intra-articular injection of antigen, including hypertrophy and hyperplasia of the synovial lining cells, pannus formation with articular cartilage erosion, and chronic infiltration of synovium by lymphocytes and plasma cells [ 13 ] . In addition, Dijkstra and colleagues [ 15 ] found macrophages in the superficial layer of the synovium, where they might secrete enzymes and oxygen radicals into the joint space, which can lead to cartilage erosion [ 9 ] . The protein levels in lavage fluid from arthritic joints in this model are low enough to allow direct testing by Western blot analysis without immunoaffinity purification, as was needed with the human aspirates.

  • Sections were evaluated in a blinded manner for histologic signs of arthritis and scored as follows: 1, synovial cell proliferation, synovial hypertrophy with villus formation and/or fibrin deposition; 2, inflammation, synovitis and/or generalized inflammation; 3, cartilage disruption, chondrocyte degeneration and/or ruffling of cartilage surface and/or dystrophic cartilage; and 4, joint destruction, cartilage erosion with abundant inflammation and pannus formation with bone erosion.

  • In view of the analogies between erosion formation in arthritis and tumor invasion in cancer, we hypothesized that activated MMP-2 and possibly MMP-9 might play an important role in the early stages of invasion of synovial pannus into bone and cartilage.

  • Although there continues to be controversy regarding the origins of the invasive cells at the junction of cartilage/bone and pannus, considerable evidence has accumulated that the lining cells in RA synovium exhibit a 'transformed' phenotype that is typical of invasive cells [ 26, 48].


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