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Example sentences for: pairings

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The 16S and 23S rRNA covariation-based structure models have undergone numerous revisions [ 23 24 25 26 27 28 ] . Today, with a significantly larger number of sequences and more advanced covariation algorithms, we search for all positional covariations, regardless of the types of pairings and the proximity of those pairings with other paired and unpaired nucleotides.
Comparative genomic analyses of orthologous drosophilid genes should aid in this endeavor, as evidenced by the recent demonstration that several conserved motifs in the 3' UTR of the pro-apoptotic gene hid are targets of the miRNA bantam [ 44 ] . Statistically significant pairings of conserved and/or overrepresented 3' UTR motifs can be assessed for complementarity to miRNAs.
These Pfam family pairings may suggest that the two domains are associated with a distinct functional class.
Experimental evidence suggests a functional role for sense-antisense pairings at a surprising variety of levels in mammalian gene regulation, including genomic imprinting [ 4, 5], RNA interference [ 6], translational regulation [ 7], alternative splicing [ 8], X-inactivation [ 9], and RNA editing [ 10].
Thus, covariation analysis is unable to predict many of the tertiary base pairings in the crystal structure, although it does identify nearly all of the secondary structure base pairings.