Example sentences for: paclitaxel

How can you use “paclitaxel” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Furthermore, transfection of CHO cells with β-tubulin classes I, II, or IVb did not produce resistance to paclitaxel [ 32 ] . The alternative hypothesis, derived from the work of Cabral and colleagues, is that rather than the tubulin isotype levels, the amount of polymerized tubulin is the critical factor that regulates response to antimitotic drugs.

  • Over the past decade paclitaxel and docetaxel have become important chemotherapeutic agents for both ovarian and breast cancers [ 1 2 ] . Considerable interest has focused on the target receptor - tubulin - and mechanisms underlying efficacy, toxicity, and drug resistance [ 7 8 23 24 27 28 ] . Whether tubulin isotype levels might determine cellular responses to antimitotic agents remains controversial.

  • Furthermore, whereas some of these data suggest a role for tubulin isotypes in drug resistance, cell growth, and differentiation, other work indicates that isotype-independent factors affecting micro-tubule polymer formation are more important than changes in isotype levels [ 32 33 34 35 ] . For example, a decrease in total polymer concentrations causes resistance to microtubule-stabilizing agents such as paclitaxel [ 34 35 ] .

  • The expression of genes encoding α-tubulin and β-tubulin seems to be developmentally regulated [ 19 ] . For example, tubulin isotype expression patterns change during the development and maturation of neurons [ 14 20 ] . Studies with paclitaxel or other antimitotic agents, such as colchicine or estramustine, indicate that drug interactions with tubulin isotypes differ [ 21 22 23 24 25 ] and might contribute to cell resistance to antimitotics [ 26 27 28 29 30 31 ] . However, one group of antimitotic agents, the vinca alkaloids, was shown to bind with similar affinity to all tubulin isotypes [ 12 ] , suggesting that alterations in drug binding affinity is unlikely to be the cause of drug resistance.

  • This 55-y-old female “never smoker” was treated for nearly 4.5 y with weekly paclitaxel and trastuzumab [17] for adenocarcinoma with bronchioloalveolar carcinoma features involving her left lower lobe, pleura, and mediastinal lymph nodes.

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