Example sentences for: overload

How can you use “overload” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The first, the ER overload response, triggers the activation of the transcription factor NFkB and the subsequent upregulation of inflammatory proteins [ 13 ] . The second, the unfolded protein response (UPR) induces three divergent cellular events: (i) the activation of transcription factor ATF6 leading to the upregulation of ER chaperones such as protein disulfide isomerase, (ii) upregulation of the pro-apoptotic transcription factor GADD153 and (iii) suppression of protein synthesis via phosphorylation of eukaryotic translation initiation factor 2α (eIF2α) by pancreatic eIF2α kinase (PEK/PERK, [ 11 12 ] ). Upregulation of the ER chaperones, GADD153 and PERK in response to a toxic insult would constitute direct evidence of an ER stress response.

  • Iron overload was detected using serum ferritin concentration, hepatic iron index, or quantitative phlebotomy in 135 probands; three women and one man had no evidence of iron overload.

  • Head out of the piazza just north of the Ospedale in the direction of Via della Colonna and the Museo Archeologico, whose important collection of ancient Egyptian, Greek and Etruscan art make it an interesting alternative to Renaissance overload.

  • Cardiomyopathy attributable to iron overload was not diagnosed in any proband.

  • Two highly conserved responses are observed under conditions of endoplasmic reticulum (ER) stress; the ER overload and unfolded protein responses [ 24 25 ] . The unfolded protein response is characterized by generalized suppression of protein synthesis and the specific induction of ER-resident proteins and GADD153 [ 24 ] . The transcription factor nuclear factor kB is activated during the ER overload response, leading to the downstream induction of pro-inflammatory proteins [ 25 ] . Therefore, the transcriptional modulation of GADD153 and IkB by mefloquine suggests that the ER might be a target of the drug.


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