Example sentences for: over-expressed

How can you use “over-expressed” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • AKT1 is over-expressed in gastric adenocarcinomas and breast cancer cell lines, AKT2 is amplified and over-expressed in pancreatic, ovarian, and breast cancers, and AKT3 is upregulated in estrogen receptor-deficient breast cancer and in androgen-independent prostate cell lines [reviewed in ref.

  • The protein product of the mdm2 oncogene is over-expressed in a considerable number of tumors [ 27 ] . This protein is a pivotal negative regulator of p53 [ 27 ] ; it interacts with the P53 protein masking its transcriptional domain and accelerating its proteasomal degradation [ 21 27 ] . The later process involves the deacetylation and ubiquitylation of the p53 protein by mdm2 [ 28 ] . Inactivation and/or degradation of p53 diminishes the cell ability to undergo apoptosis [ 21 ] . Conversely, p53 may influence mdm2.

  • One gene that was over-expressed in islets from the type 2 diabetic subject, was the DNA glycosylase 8-OxoG DNA glycosylase (Ogg1).

  • The secreted form has been referred to as megakaryocyte potentiating factor (MPF) for its ability to stimulate the megakaryocyte colony forming activity of murine IL-3 in mouse bone marrow cell culture [ 23 24 ] . Mesothelin expression is induced in a variety of cancers including ovarian, pancreatic, lung, and cervical cancer [ 25 26 ] . The soluble portion of mesothelin has drawn attention as a potential serum tumor marker since it is highly over-expressed in patients with ovarian carcinomas and pancreatic adenocarcinomas [ 27 28 ] .

  • Small-scale growth cultures showed that all three mutants were over-expressed at levels comparable to those of wild-type L1.


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