Example sentences for: outside-in

How can you use “outside-in” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • In particular, little structural insight has been obtained for early outside-in intracellular events following ECM–integrin binding, e.g., upon ECM engagement.

  • Overall, these results support the notion that resveratrol and shear stress induce elongation of the EC cytoskeleton via an overlapping outside-in signaling mechanism.

  • This is achieved by “outside-in” signaling, i.e., when an integrin binds to the extracellular ligand, it clusters with other bound integrins, resulting in the formation of highly organized intracellular complexes known as focal adhesions that are connected to the cytoskeleton.

  • Ligand occupancy and receptor clustering initiates outside-in signaling that, in turn, regulates a variety of cellular responses (see below).

  • Although many intracellular components involved in outsidein signaling have been identified, and much has been learned about various signaling pathways involved in outside-in signaling (Giancotti and Ruoslahti 1999), a molecular view of how the various events occur in time and space is still very uncertain.


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