Example sentences for: osteoclasts

How can you use “osteoclasts” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Osteoclasts were large, multinucleated cells, and expressed high levels of tartrate-resistant acid phosphatase (TRAP).

  • Less robust cultures with 80-150 osteoclasts per well were more accurately quantitated by counting individual osteoclasts (Fig.

  • The molecular signals required for osteoclastogenesis have recently been elucidated [ 1 4 5 ] . Receptor-activator of NFκB ligand (RANKL), a tumor necrosis factor superfamily ligand expressed by stromal cells, osteoblasts, and activated T cells, binds to its cognate receptor-activator of NFκB (RANK) receptor on macrophages/monocytes, inducing a signal that gradually transforms the macrophages into osteoclasts over a period of several days [ 6 7 ] . While this interaction occurs largely in the bone microenvironment, it has been shown that monocytes from the spleen, peripheral blood, and synovium are all capable of RANKL-dependent osteoclast formation [ 8 ] . Convincing evidence has been generated indicating that the RANK-RANKL interaction is absolutely required for osteoclastogenesis [ 7 ] ; in the absence of these molecules, osteoclastogenesis cannot occur [ 9 ] .

  • TRANCE is known to be expressed by activated T cells, and can stimulate dendritic cells and osteoclasts [ 18].

  • Hofbauer et al suggest that the stimulation of the pool of M-CSF precursors to committed osteoclastogenesis by RANKL may be one of the central pathophysiologic pathways involved in increasing the number of osteoclasts in osteoporosis.


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