Example sentences for: osteoclasts

How can you use “osteoclasts” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Osteoclasts were large, multinucleated cells, and expressed high levels of tartrate-resistant acid phosphatase (TRAP).

  • Less robust cultures with 80-150 osteoclasts per well were more accurately quantitated by counting individual osteoclasts (Fig.

  • The molecular signals required for osteoclastogenesis have recently been elucidated [ 1 4 5 ] . Receptor-activator of NFκB ligand (RANKL), a tumor necrosis factor superfamily ligand expressed by stromal cells, osteoblasts, and activated T cells, binds to its cognate receptor-activator of NFκB (RANK) receptor on macrophages/monocytes, inducing a signal that gradually transforms the macrophages into osteoclasts over a period of several days [ 6 7 ] . While this interaction occurs largely in the bone microenvironment, it has been shown that monocytes from the spleen, peripheral blood, and synovium are all capable of RANKL-dependent osteoclast formation [ 8 ] . Convincing evidence has been generated indicating that the RANK-RANKL interaction is absolutely required for osteoclastogenesis [ 7 ] ; in the absence of these molecules, osteoclastogenesis cannot occur [ 9 ] .

  • TRANCE is known to be expressed by activated T cells, and can stimulate dendritic cells and osteoclasts [ 18].

  • Hofbauer et al suggest that the stimulation of the pool of M-CSF precursors to committed osteoclastogenesis by RANKL may be one of the central pathophysiologic pathways involved in increasing the number of osteoclasts in osteoporosis.

How many words do you know? Try our free vocabulary size test!


Search for example sentences

Loading Loading...