Example sentences for: osteoclastogenesis

How can you use “osteoclastogenesis” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Based on the phenotype of knockout mice, it has become clear that TRAF6 is the critical adapter molecule required for RANK signaling during osteoclastogenesis [ 35 ] . The importance of TRAF6 has been further explored in deletion studies, which correlated its various domains with its osteoclastogenic potential [ 46 ] . A link between IFN-γ and RANK signaling via TRAF6 has also been demonstrated in bone marrow cultures, in which IFN-γ was shown to accelerate the degradation of TRAF6 [ 38 ] . In our studies, however, we failed to observe this TRAF6 degradation, as its expression remained constant in both short-term and long-term cultures under conditions where IFN-γ completely inhibited osteoclastogenesis.

  • With respect to osteoclast formation, IFN-γ is known to potently inhibit RANKL-mediated osteoclastogenesis in both spleen-derived macrophage cultures and bone marrow coculture systems [ 19 20 21 ] . It has also been demonstrated that mice defective in IFN-γ signaling have a more rapid onset of arthritis and bone resorption compared with wild-type mice, suggesting a protective role of IFN-γ in early arthritis [ 21 22 ] .

  • The proinflammatory cytokines tumor necrosis factor alpha, IL-1, and IL-6 augment osteoclastogenesis [ 9 10 11 ] , while IL-10, IL-12, IL-18, and IFN-γ antagonize osteoclastogenesis in vitro [ 12 13 14 15 ] . It is probable that cytokines play a vital role in the delicate balance of bone remodeling, and that therapies based upon their natural biological function can be designed.

  • The role of S. aureus -induced TRAIL in apoptosis and osteoclastogenesis in vivo is currently being examined.

  • The present results underscore the importance of developing a complete understanding of osteoclastogenesis in vivo with regard to location, time, and the signal transduction pathways involved.


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