Example sentences for: osteoclast

How can you use “osteoclast” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • These effects were irreversible and not caused by inhibition of proximal signaling at the level of STAT1 or TRAF6, suggesting that resistance to IFN-γ is caused by a complex differentiation program specifying the osteoclast fate.

  • Using this technique, we analyzed cytokine (IL-2, IL-4, IL-6, IL-10, IL-13, IFN-γ, TNF-α, and LT-α), activation marker (CD154 [CD40 ligand] and TRANCE - also called receptor activator of nuclear factor-κ B ligand [RANKL] or osteoclast differentiation factor [ODF]), and chemokine receptor expression by individual CD4 +memory T cells isolated from rheumatoid synovium and blood.

  • As a consequence, osteoclast dysregulation leads to osteoporosis (decreased bone mass caused by excess osteoclast activity) or to osteopetrosis (increased bone mass caused by insufficient osteoclast activity).

  • These cells have been demonstrated to recapitulate critical aspects of osteoclast formation and activity, including bone resorption, expression of calcitonin receptor, multinuclear fusion, and TRAP expression [ 6 34 ] .

  • The potency of IFN-γ as a macrophage activator and osteoclast inhibitor suggests a prominent role for T cells and/or NK cells in the regulation of bone resorption, as these cells constitute the major source of IFN-γ [ 18 ] . A link between activated T cells and osteoclast inhibition by IFN-γ has been highlighted in a report by Takayanagi et al ., providing the first in vivo evidence that the immune system may influence osteoclastogenesis [ 38 ] . Interestingly, other groups have demonstrated that activated T cells induce osteoclastogenesis via upregulation of surface RANKL, presenting a dilemma regarding the role of activated T cells in osteoclastogenesis [ 20 40 45 ] .


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