Example sentences for: osteoclast

How can you use “osteoclast” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Human RANKL was a gift from Immunex (Seattle, USA) and was used to verify the efficiency of GST-RANKL protein as verified by splenic osteoclast induction.

  • The strength of the early RANKL signal may be altered in the setting of inflammatory bone diseases such as rheumatoid arthritis, in which high levels of RANKL expressed on either synovial cells or infiltrating T cells [ 43 44 ] may induce osteoclast formation despite the presence of exogenous or endogenous IFN-γ.

  • In the present study in the mouse, differentiation of osteoclast progenitors appears to be dependent on the direct interaction of bone marrow stromal cells with Ocl precursor cells [ 19, 20].

  • The CD98 (4F2, FRP-1) molecule, a cell surface disulfide-linked heterodimer, was originally described as a T cell activation antigen [ 1 ] , and later was shown to provide a co-stimulatory signal for CD3-mediated T-cell activation [ 2 ] , independent of CD28/CD80/CD86 interaction [ 3 ] . In other studies, triggering of human monocyte CD98 could suppress T cell proliferation [ 4 ] , or promote homotypic cell aggregation of monocytes [ 5 ] . Also, CD98 may be a target antigen for natural killer cells [ 6 ] , may mediate fusion of blood monocytes leading to osteoclast formation [ 7 8 ] , and may modulate hematopoietic cell survival and differentiation [ 9 ] .

  • 7 (RAW cells) or splenic macrophages from CBA/BL6 mice as osteoclast precursors.


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