Example sentences for: osteoarthritis

How can you use “osteoarthritis” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • For example, a study by Shipley on the treatment of osteoarthritis with the homeopathic remedy Rhus tox reported no difference in outcome compared to placebo.

  • Within the MMP family, MMP-1 (collagenase-1) and MMP-13 (collagenase-3) are expressed in arthritic joints, and efficiently degrade type II collagen [ 9 ] . MMP-13 is more effective than MMP-1 in cleaving type II collagen, but it is debated which is the principal collagenase in vivo [ 10 11 ] . These enzymes have been implicated in the pathology of rheumatoid arthritis (RA) and osteoarthritis (OA), and have long been therapeutic targets [ 12 ] . Historically, inhibition of MMP-active sites has been a strategy; however, with wide-ranging side-effects and lack of efficacy, these studies are proving unfruitful in providing an effective drug [ 13 ] .

  • As a novel approach to therapy, we and other workers have focused on developing the methods for local transfer of genes encoding therapeutic agents to the joint [ 13 14 15 16 17 18 19 ] . This strategy also can be applied to the treatment of osteoarthritis and for aiding the repair of the cartilage and other intra-articular tissues.

  • Given that TGF-β1 is able to induce new matrix synthesis from chondrocytes in culture as well as able to block inflammation in vivo , it has been proposed that local intra-articular gene transfer of TGF-β1 could be therapeutic for the treatment of rheumatoid arthritis as well as osteoarthritis.

  • To determine which of these angiogenic factors may play a role in RA, we investigated both the distribution and the levels of mRNA for Tie1, Tie2, Ang-1 and Ang-2 in synovial tissue obtained from RA patients, compared with that from subjects with osteoarthritis (OA) and normal tissues.


How many words do you know? Try our free vocabulary size test!


Search

Search for example sentences

Loading Loading...
Quantcast