Example sentences for: incontinence

How can you use “incontinence” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • However, alpha1a-adrenoceptor gene polymorphism was found to play no role in clozapine-induced urinary incontinence [ 38 ] .

  • persistent urinary incontinence).

  • In terms of profile risperidone binds 5HT2A>>alpha1=H1>D2>alpha2 (Table 1 [ 12 16 ] ). Risperidone displays little or no affinity for the muscarinic receptor [ 11 12 16 ] and yet risperidone therapy has been associated with urinary incontinence (28% in some cases [ 17 18 19 ] ).

  • Clozapine is a widely used atypical neuroleptic with affinity for multiple receptors, including dopamine, serotonin, alpha adrenergic, muscarinic and histaminergic receptors [ 1 2 ] . Although clozapine is effective in the treatment of schizophrenia refractory to traditional antipsychotic medication, it also has a number of significant side effects ranging from the potentially fatal but rare agranulocytosis to weight gain, constipation, seizures and urinary incontinence [ 3 ] . Urinary problems have been reported in the clinical literature with incontinence present in up to 44% of patients [ 4 ] and enuresis in 27% of patients [ 5 ] . Since clozapine has potent anti-muscarinic and anti-alpha adrenergic effects [ 2 ] , it has been proposed that peripheral effects on the lower urinary tract might be responsible for the micturition disturbances [ 6 ] . Incontinence has also been reported following therapy with other atypical neuroleptics such as risperidone [ 7 8 9 ] and recently, olanzapine [ 10 ] .

  • Urinary incontinence as a result of olanzapine [ 12 ] or clozapine [ 15 ] therapy was treated effectively with ephedrine (alpha adrenergic receptor agonist), suggesting a possible alpha1 effect.


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