Example sentences for: immunodominant

How can you use “immunodominant” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Of the mice immunized with the PD peptides, that are not immunodominant in NOD mice, 43% (3/7) developed anaphylactic shock at the time of challenge with PD peptides (Table 1).

  • Unfortunately, some synthetic peptides, including some corresponding to immunodominant epitopes (those which cause the biggest part of the immune response) from tumor antigens, only seem to bind MHC class I molecules with medium to low affinity and/or are recognized by specific T cells with relatively low avidity.

  • It was of interest that the unmodified protease induces antigen-specific IgG in the absence of detectable immunodominant T cell epitopes.

  • Indeed, we originally included the PD-immunized group because PD peptides are the immunodominant epitopes that are presented in transgenic NOD.PD mice that do not get diabetes [ 4 5 ] . Because of their unknown, and potentially even protective, role in the diabetes-resistant NOD.PD strain, we felt that it was important to assess whether, through a peptide therapy regimen, PD peptides might be able to protect against diabetes by shifting T H 1 to T H 2 responses in NOD mice.

  • In accord with these results, immunization of the NOD mice with PD peptides produced a less robust specific IgG1 antibody response than did immunization with the immunodominant G7 peptides (see below).


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