Example sentences for: immunodominant

How can you use “immunodominant” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • For example, administration of GAD65 to young NOD mice has been shown to prevent insulitis and diabetes [ 8 9 ] , apparently via induction of CD4+ regulatory T cells with a T H 2 phenotype [ 10 ] . Similarly, treatment with immunodominant peptides of myelin can prevent or reverse experimental autoimmune encephalomyelitis (EAE), a T H 1-associated inducible "autoimmune" disorder that is widely used as a model for human multiple sclerosis [ 11 12 13 ] .

  • Unfortunately, some synthetic peptides, including some corresponding to immunodominant epitopes (those which cause the biggest part of the immune response) from tumor antigens, only seem to bind MHC class I molecules with medium to low affinity and/or are recognized by specific T cells with relatively low avidity.

  • However, in the thymus a splice variant results in the lack of thymic expression of an immunodominant peptide.

  • In accord with these results, immunization of the NOD mice with PD peptides produced a less robust specific IgG1 antibody response than did immunization with the immunodominant G7 peptides (see below).

  • Of the mice immunized with the PD peptides, that are not immunodominant in NOD mice, 43% (3/7) developed anaphylactic shock at the time of challenge with PD peptides (Table 1).


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