Example sentences for: immunocompetent

How can you use “immunocompetent” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Since human infection with Cryptosporidium parvum was first documented in 1976 [ 1 ] , this protozoan parasite has been recognized worldwide as a major cause of diarrheal disease in humans [ 2 ] . In healthy, immunocompetent persons, C. parvum causes a self-limited diarrheal illness (cryptosporidiosis); however, in persons with severe immunosuppression, particularly those infected with the human immunodeficiency virus (HIV) and who have developed acquired immunodeficiency syndrome (AIDS), the diarrhea can be prolonged, severe, and life-threatening [ 3 4 ] . Currently there are no effective chemotherapeutic agents against cryptosporidiosis [ 5 ] . Cryptosporidium oocysts are found in the feces of infected humans, livestock, and wild animals [ 6 ] . Humans acquire the infection through person-to-person or animal-to-person contact, ingestion of fecally-contaminated water or food, or contact with fecally-contaminated environmental surfaces [ 7 ] .

  • After four serial passages in the immunocompetent mice, the infection became completely refractory to ACV treatment.

  • A similar study conducted among immunocompetent persons in the same geographic region found that cryptosporidiosis was only associated with foreign travel but not tap water consumption [ 34 ] . This discordance in results supports the observation that host susceptibility, i.e., immune status, is the primary determinant of developing cryptosporidiosis among AIDS patients.

  • Sub-optimal therapy of immunocompetent mice with either VCV or FCV did not readily select for HSV-mutants resistant to either ACV or PCV, suggesting that selection of resistance with either prodrug remains difficult using this system.

  • Of the 69 immunocompetent cases who did not participate in the case-control study and for whom we had data, broad risk factor information was only available for 17.


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