Words similar to i-a

Example sentences for: i-a

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T1DM susceptibility in the NOD mouse is linked to I-A g7, the murine MHC class II gene that encodes a histidine at position 56 and a serine at position 57 in the β chain, in place of the more frequent proline 56β and aspartic acid 57β [ 3 ] . The development of diabetes is prevented in NOD.PD mice (which are NOD mice with I-A g7) that carry a β chain transgene with site-specific mutations that restore proline and aspartic acid at positions 56β and 57β, respectively [ 4 ] . Furthermore, because of the two amino acid changes in the additional (transgenic) MHC class II allele β chain in NOD.PD mice, NOD.PD mice recognize three additional peptide epitopes in the glutamic acid decarboxylase 65 (GAD65) autoantigen [ 5 ] .
10 TCR transgenic mice specific for ovalbumin peptide residues 323-339 (OVA323-339) and restricted by I-A d [ 20 ] were backcrossed onto BALB/cJ background (>16 generations).
Data for a number of A *0201, A *6801, B *0801, B *2705, B *3501, B *5301, H-2K B, H-2D B, H-2D D, H-2L D, DR1, DR2, DR3, DR4, I-A DMHC-peptide crystal complexes are available in the PDB.
In an attempt to induce a T H 2 shift, [ 19 20 ] 8 to 9 week old female NOD mice (I-A g7) were immunized by 3 weekly i.p.
injections of the immunodominant G7 peptides (GAD 206-226/217-236/286-300) or of the additional GAD65 peptides identified in NOD.PD mice (I-A NOD/PD) (GAD 333-345/K458-470R) in IFA [ 5 ] . As noted in the background section, PD peptides are not immunodominant in NOD mice.