Example sentences for: defective

How can you use “defective” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Glucose repression of transcription is defective in nrg1Δ

  • Our results provide direct genetic evidence for these functions of TECs, by showing that these processes are defective in mutants with a primary TEC differentiation defect (the Hoxa3,Pax1 compound mutants).

  • The accumulation of non-secreted protein in mutants defective in ER to Golgi transport leads to proliferation of the ER [ 37 44 ] . The membrane proliferation seen by TEM in npa1-1/sec23 and npa2-1/sec13 cells (Figure 4) and the coincident mislocalization of Nups (Figure 3and data not shown) prompted us to test if Nups were accumulating at the ER.

  • in vitro proliferation, decreased production of interleukin-2 [ 2 6 7 8 ] and 11-2 receptor [ 7 9 10 ] , and defective progression thought the cell cycle [ 11 12 ] . HIV +infection likewise induces a progressive suppression in proliferation of both CD4 +and CD8 +T cells in vitro that correlates with clinical severity, as well as diminished 11-2 production [ 13 14 15 16 ] . However, even stronger parallels exist between immune phenomena in aging and AIDS than suppression of T cell proliferation and 11-2 production.

  • The following results support this hypothesis: 1) sα i2 and α i2 are equally labeled by a pulse of 3H-myristate, although much less sα i2 protein is detected; 2) sα i2 displays a propensity to localize to potential aggresome-like structures, and this localization is greatly enhanced by proteasome inhibitor treatment; 3) the α i2 A327S mutant, previously shown to be unstable and defective in guanine-nucleotide binding, shows a similar pattern of subcellular localization ( i.e., intracellular membranes rather than PM); 4) βγ over-expression increases expression of sα i2 and promotes PM localization of sα i2 and α i2 A327S, but βγ co-expression does not prevent sα i2 localization to potential aggresome-like structures when cells are treated with proteasome inhibitors; and 5) pulse-chase analysis indicates that sα i2 is rapidly degraded.


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