Example sentences for: dedifferentiation

How can you use “dedifferentiation” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Infection of cultured podocytes with replication incompetent HIV-1 demonstrated that HIV-1 gene expression leads to the proliferation and dedifferentiation of the infected podocytes [ 6 7 8 ] , recapitulating the phenotypes observed in HIVAN specimens [ 9 10 ] . Similarly, renal expression of replication incompetent HIV-1 proviral transgenes in mice and rats produces a proliferative renal lesion that is indistiguisable both histopathologically and clinically from human HIVAN [ 11 12 13 14 ] . These observations raise the possibility that HIV-1 gene products may interact with mitogenic pathways in infected renal epithelium to cause aberrant cell-cycle engagement.

  • For example, during salamander limb regeneration, cells from muscle, bone, cartilage, nerve sheath, and connective tissues participate in the dedifferentiation process to form a pool of proliferating progenitor cells known as the regeneration blastema (Figure 1) (Chalkley 1954; Bodemer and Everett 1959; Hay and Fischman 1961; Wallace et al.

  • They then essentially starved the cells so that they shut down normal metabolic function, entering a "quiescent" state, in which dedifferentiation apparently occurs.

  • HIV-1 expression in cultured podocytes recapitulates the phenotypic abnormalities induced by HIV-1 expression in infected podocytes in vivo, specifically proliferation, loss of contact-mediated growth control, and dedifferentiation [ 6 7 8 ] . To determine if these phenotypes were marked by enhanced cyclin D 1 and phospho-pRb (Ser780) expression, we utilized the podocyte cell-culture protocol developed by Rieser et al.

  • Given the high-tech world of modern biology, the method by which the Scottish team managed to provoke this extraordinary dedifferentiation is almost old-fashioned in its simplicity.


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