Example sentences for: decondensation

How can you use “decondensation” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • In this case, nucleoplasmin acts to exchange the sperm specific basic proteins, which allow the dense packing of DNA in sperm, with the histones H2A and H2B, thus effecting chromatin decondensation [ 5 6 ] . Phosphorylation of nucleoplasmin appears to be important in regulating this activity, as heavily phosphorylated nucleoplasmin is significantly more active [ 7 ] .

  • These covalent and non-covalent catalytic actions on the chromatin can result in condensation or decondensation of chromatin, either locally or on the chromosomal scale, and thereby regulate access of transcription factors and other proteins to the chromatin.

  • In concert with the unrelated acidic protein N1/N2, which binds histones H3 and H4, they act together and with other factors to assemble nucleosomes [ 2 3 ] . In addition to assembly, nucleoplasmin and other proteins are involved in the chromatin remodeling and nucleosome disassembly that occurs, for example, during transcription to allow the access of transcription factors to nucleosomal DNA [ 4 ] . Another major function of nucleoplasmin is the decondensation of sperm chromatin at fertilization.

  • A nucleic acid binding domain in the C-terminus of nucleophosmin is also lacking in NPM3 and nucleoplasmin, but the known functions of nucleoplasmin in nucleosome assembly and sperm decondensation suggest that this protein, and possibly NPM3, can accomplish intermolecular reactions involving nucleic acids in other ways, perhaps by associating with other proteins that have this binding activity.


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