Example sentences for: deadenylase

How can you use “deadenylase” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Until now, the only known deadenylase in vertebrates is a poly(A)-specific exoribonuclease, PARN, a member of the RNaseD family of exonucleases [ 34 ] . The present results therefore propose a series of new putative mammalian deadenylases, and predict a set of residues that should be functionally important for all yCCR4-related proteins.

  • Since the presently characterized mammalian yCCR4 ortholog has conserved the ability to bind yPOP2 homologs and displays high sequence similarities with yCCR4 in the nuclease core domain, it suggests that the mammalian yCCR4 orthologs might also be associated with a deadenylase function.

  • yCCR4 was also shown to be a component of the major yeast cytoplasmic mRNA deadenylase complex, and to be required for efficient poly(A)-specific mRNA degradation [ 14 15 ] . Interestingly, this yCCR4-dependent activity copurifies with yPOP2.

  • Interestingly, in yeast only one CCR4-POP2 complex has been described until now, whereas CCR4/POP2 interactions have been found associated with both transcription regulation and mRNA deadenylase activity.

  • Second, yCCR4 was shown to be a component, in association with yPOP2, of the major yeast cytoplasmic mRNA deadenylase complex, and to be required for efficient poly(A)-specific mRNA degradation [ 14 15 ] . yCCR4 might be a catalytic subunit of this complex, because of its nuclease-like domain.


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