Words similar to deacetylase
Example sentences for: deacetylase
How can you use “deacetylase” in a sentence? Here are some example sentences to help you improve your vocabulary:
A PSI-BLAST search started with the N-terminal SBHM from the Aquifex aeolicus DDRP β' subunit detected several SBHMs from proteins other than the β' subunit, such as acetylornithine deacetylase (E = 2 × 10 -7, iteration 2), the C-terminal region of bacterial cytochrome F (E = 10 -4, iteration 2), biotin carboxyl carrier domain of biotin transcarboxylases (E = 6 × 10 -4, iteration 2) and the phosphotransferase system enzyme II (E = 10 -3, iteration 2).
Studies have shown BRCA1 is upregulated in cells treated by DNA damaging agents such as cisplatinum [ 4 ] . BRCA1 has been shown to interact with DNA repair proteins such as Rad50 and Rad51, the tumor suppressor genes RB and BRCA2, transcriptional factors (RNA pol II, histone deacetylase complex, ctIP) as well as influence numerous cyclins and cyclin dependent kinases contributing to cell cycle regulation [ 5 6 7 8 9 10 11 12 ] . More recently, BRCA1 has been shown to influence apoptosis in a p53 independent manner [ 13 ] . This apoptotic response involved the c-jun kinase (JNK) pathway, though the details of this mechanism remain unclear [ 14 ] .
Thus, histone deacetylase inhibitors - Butyrate and Trichostatin A - can rescue MHCII-inducibility in bladder carcinoma cells [ 14 ] and restore constitutive MHCII expression in plasmacytoma cells [ 35 ] . In addition to acetylation, transcriptional activity of chromatin is also regulated through phosphorylation (reviewed in Ref.
It was reported that some agents, e.g. histone deacetylase inhibitors [ 14 ] or DNA methylation inhibitors [ 15 ] , can rescue the IFNg inducibility of MHCII in cultured tumor cells.
Sir2 (the mammalian homolog is SIRT1) is a nicotinamide-adenine-dinucleotide-dependent histone deacetylase that interacts with numerous transcription factors to silence gene transcription.
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