Words similar to ddrp

Example sentences for: ddrp

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Proliferation of the Sandwich-Barrel Hybrid Motif and lineage-specific innovations of the large subunits of bacterial DDRP
Visual examination of the structure of this insert domain revealed a topology with elements of both a sandwich and a barrel, and two "waist"-like structures that are characteristic of the sandwich-barrel hybrid motif (SBHM) fold [ 75 76 ] (see also the SCOP database [ 65 ] ). The SBHM fold is present in biotin/lipoate carrier domains and their homologs found in a variety of enzymes and transporters [ 76 ] . A DALI search with this insert domain from the β subunit of Thermus DDRP showed similarity to the SBHMs from various biotin/lipoate-binding enzymes, such as acetyl-CoA carboxylase (1bdo) or dihydrolipoamide acetyltransferase (1iyu) with Z scores of ~6 and RMSD ~2.
Although the cores of the two DDRP subunits are homologous and are likely to have evolved from a common ancestor (see discussion below), they have completely different sets of conserved residues and contribute distinct moieties to the catalytic cleft (Figs.
7), but there is no evidence for such a role in the DDRP β subunits.
The region of sequence similarity between the RDRPs and the β' subunits of DDRPs, that was detected in the searches described above, almost precisely mapped to the DPBB-fold catalytic domain of DDRP.