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Example sentences for: alphab

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Both alphaA and alphaB can bind specifically to actin, in vitro [ 13 ] and in vivo [ 14 ] . Although actin filament formation has been shown to be necessary for differentiation of lens epithelial cells [ 15 ] , the significance of alpha-crystallin's interaction with actin in differentiation is not known.
The morphological observations presented in this study demonstrate that fiber cells in lenses lacking alphaA and alphaB fail to elongate symmetrically from the bow region and therefore do not establish the typical "onion skin" conformation in which cells extend from the anterior epithelium to the posterior capsule.
Targeted disruption of the mouse alphaB gene, however, resulted in lenses similar in size to aged-matched wild type lens with no cataracts reported [ 23 ] . This indicates that alphaA may play a greater role in maintaining the transparency of the lens then alphaB.
Alpha-Crystallin is comprised of two polypeptides, alphaA-crystallin (alphaA) and alphaB-crystallin (alphaB), which share 55% amino acid sequence homology [ 1 ] . They are the most abundant proteins in lens fiber cells [ 2 3 ] and exist as heteroaggregates of approximately 800 kDa that can undergo inter-aggregate subunit exchange [ 4 ] . The expression of these two proteins in the lens epithelium, however, is not uniform throughout different regions of the anterior epithelium.
None of these morphological differences have been reported in the single alphaA or alphaB knockout mice.